Gastroparesis, a chronic motility disorder characterized by abdominal pain, nausea, vomiting and delayed gastric emptying of solid food in the absence of a mechanical obstruction. 

The primary management of gastroparesis involves patient education and dietary therapy; correcting fluid, electrolyte and nutritional deficiencies; identifying and treating the cause of delayed gastric emptying (for example, diabetes mellitus; medications); and palliating symptoms with pharmacological agents as first-line therapies.

 nVNS was very well tolerated and no adverse events were reported during or after treatment. Responders showed significant symptom improvement in the Patient-Reported Outcomes  Measurement Information System (PROMIS) gastrointestinal and pain symptom subscales

Short-term non-invasive vagal nerve stimulation led to improved cardinal symptoms and accelerated gastric emptying in a subset of patients with idiopathic gastroparesis. (Gottfried-Blackmore et al., 2019)